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Clinical manifestations of low testosterone include sexual dysfunction, fatigue, increase in body fat, loss of muscle mass and decrease in physical performance. Men with low-t have decreased lean muscle mass compared to men with normal testosterone levels. The administration of testosterone in men. Low testosterone is associated with deterioration of the musculoskeletal system, commonly manifesting as osteopenia (borderline osteoporosis) and sarcopenia. Low testosterone levels have been associated with decreased muscle mass. Increase your muscle mass, and help prevent bone loss. Testosterone replacement may improve your sexual desire, increase your muscle mass, and help prevent bone loss. Many men with low testosterone levels report. Testosterone is the primary sex hormone in men. Testosterone levels can affect sex drive, erections, mood, bone density, and muscle mass. Testosterone helps build muscle, and low testosterone can cause loss of muscle mass. 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